This website is an excellent resource for physiological, anatomical and biochemical parameters for a variety of animal species and is helpful in design preclinical development programs:  http://www.interspeciesinfo.com

A helpful new FDA document was recently issued describing the FDA’s good review practices for INDs.  See this link:  http://www.fda.gov/downloads/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/ManualofPoliciesProcedures/UCM349907.pdf